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Semaglutide works by: Enhancing insulin secretion in a glucose-dependent manner, which helps regulate blood sugar levels Suppressing glucagon release , reducing hepatic glucose output Slowing gastric emptying , which prolongs satiety and reduces appetite Acting on appetite centres in the brain , particularly the hypothalamus, to reduce hunger and food intake These combined effects led to significant weight loss in clinical trials (STEP programme), typically in the range of 1015% of body weight over 68 weeks, though individual results vary considerably

Data 52 , 21662170 (2007) F.E