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This inhibition disrupts glutathione synthesis, which is critical for managing oxidative stress, thus increasing cancer cell susceptibility to L-ASNase (130, 131)

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The current European Union (EU) recommended daily intake is 1.5 micrograms for infants and children under six, 2.5 micrograms for seven to 10-year-olds, 3.5 micrograms for 11 to 14-year-olds, four micrograms for everyone over 15, increasing to 4.5 micrograms during pregnancy and five micrograms for breastfeeding women (EFSA, 2015)

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