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Collectively, these findings indicate that the primary conclusions for weight and waist circumference are robust, while outcomes related to insulin resistance appear more sensitive to study exclusion

p62 competes with NRF2 for binding to KEAP1, and this interaction induces a dependent autophagic degradation of KEAP1 and subsequent NRF2 stabilization and activation in both MEFs and HEK293 cells [198]

Caffeines antagonistic effect against adenosine receptors prevents adenosine-dependent vasodilatation and increases adenosine concentrations

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