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For instance, pharmacokinetic vitamin-drug interaction studies have indicated a decreased uptake of the anticancer drug antifolate methotrexate in cancer cells, and the complexation of methotrexate and doxorubicin C into inactive adducts by riboflavin, thereby reducing the efficacy of these drugs 145

In order to optimize the effectiveness of therapy, the competing immune reactions must be carefully handled, which emphasizes the necessity of exact management of the source and composition of EXOs in medicinal preparations (Li et al., 2022e)