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While the observed associations do not establish causality, they highlight the importance of vigilance for potential NAEs during treatment, particularly given the heterogeneous temporal patterns of onset across events

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10.1016/j.tins.2008.02.005 354

These enzymes function in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione