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The effect of meglitinide binding is similar to the effect of sulfonylureas with binding resulting in the closure of the KATP channel leading to cell depolarization and calcium influx resulting in insulin secretion (22,42,43)

Indications: FDA : Topical anesthesia of the upper respiratory tract (due to its combined vasoconstrictor & local anesthetic properties) Off Label : Use in Emergency Department as one ingredient in a topical anesthetic solution called TAC (containing: Tetracaine, Adrenaline & Cocaine) that is applied to a wound prior to cleaning & suturing Contraindications: Hypersensitivity to ester anesthetics Side Effects: Acute signs of systemic toxicity include can include multiple signs of both CV & CNS stimulation: tachycardia hypertension hyperthermia mydriasis seizures cardiac arrhythmias (multiple contributing variables: Na & K channel block, possible coronary vasoconstriction) Acute effects associated with cocaine abuse

10.1016/j.scitotenv.2023.162101 219 Jimnez-ArroyoC.TamargoA.MolineroN.ReinosaJ

8.7%), nausea (21.7%, 22.4% vs