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There are also certain drugs and health conditions that can increase the likelihood of developing a B12 deficiency such as: alcohol abuse, antacid use, smoking, celiac disease, other digestive concerns, pregnancy, a strict vegetarian or vegan diet, and even natural aging

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While some lean mass loss inevitably occurs during significant weight reduction, the rate is typically 20-25% of total weight lost on tirzepatide compared to 30-40% with diet-only approaches

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