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Ovarian injury in Non-malignant disease contexts Beyond the well-recognised gonadotoxicity of cancer therapy, a spectrum of non-cancerous disordersincluding genetic, autoimmune diseases and environmental factorscan compromise ovarian integrity and precipitate POI ( Fig

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In combination with immunological cross-reactivities and functional data they formed the basis of an evolutionary tree (Figure 1 shows a phylogram based on the aminoacid sequences of the 18 distinct gene products occurring as soluble dimeric proteins in humans