glutathione cancer cell Application of depletion in therapy: Enhanced ROS-based therapy, ferroptosis, and chemotherapy Frontiers | Glutathione Peroxidase 4

Glutathione in brain disorders and aging

Distribution, Biosynthesis, and Disease Associations Glutathione is found both intracellularly and in the extracellular matrix, with particularly high levels in: Lung tissue Brain tissue Liver tissue It is synthesized endogenously through a two-step enzymatic pathway involving -glutamylcysteine synthetase and glutathione synthetase

10.1016/0006-291X(83)91789-8

The sulfhydryl (thiol)-containing tripeptide glutathione (GSH) is synthesized and maintained at high concentrations in virtually all cells and is one of the principal mechanisms by which reactive oxygen species (ROS) are eliminated [3, 7, 8]