Reactive oxygen species generation and cellular regulation Overloaded Pt drugs produce toxic ROS, which are strongly associated with PIPN ( Pt-induced ROS production easily breaks the balance of endogenous ROS and cellular antioxidant systems to trigger oxidative stress and mitochondrial dysfunction, resulting in the damage or loss of DRG cells containing abundant ROS-sensitive phospholipids ( Regarding ion channels, TRP play a key role in aggravating cold abnormal pain, among which, TRPA1 and transient receptor potential melastatin 8 (TRPM8), as cold-sensitive receptors, could be activated by ROS ( 2+ influx ( Some voltage-gated ion channels, namely, the potassium (K + ), calcium (Ca 2+ ), and sodium (Na + ) channels, could also be oxidized by ROS to consequently affect DRG neuronal excitability and conduction
however, 500 mg per day is considered suitable
IV delivery bypasses the digestive system, placing nutrients directly in the bloodstream at concentrations the gut cannot match
MadsenKLBuchAECohenBHFalkMJGoldsberryAGoldsteinAet al
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