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Pregabalin, which was the first drug to gain FDA approval for diabetic neuropathy, is an anticonvulsant and analgesic that works by binding to the alpha-2-delta subunit of voltage-gated calcium channels in the central nervous system

Evidence Quality: AOD 9604 vs Tirzepatide Once more: Tirzepatide has undergone rigorous human clinical trials with thousands of participants, possesses published results, and continues to demonstrate superior real-world effectiveness when compared to other GLP-1 agonists

Side effects such as upper respiratory infection, low white blood cell count, and suicidality necessitate more extensive trials to confirm safety (Papp 2012

& Kroemer, G