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Add-on Combination Therapy with Glimepiride, with or without Metformin A total of 441 patients with type 2 diabetes participated in a 24-week, randomized, double-blind, placebo-controlled study designed to assess the efficacy of JANUVIA in combination with glimepiride, with or without metformin

While acknowledging the strengths of the study, such as participant criteria, low drop-out rates and high adherence, the researchers also acknowledged limitations, including the relatively short intervention duration and the absence of a third intervention group receiving synbiotics alongside a placebo

Most people reach their maximum benefit between 12-18 months

Photos of yourself from earlier years are also useful if your goal is to recapture a previous look