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Description

When IGFBPs are hydrolyzed by proteases, free IGF-1 binds to IGF-1R on the cell membrane to mediate the corresponding biological effects (8)

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Reactive oxygen species (ROS), including superoxide anion (O 2 ), hydrogen peroxide (H 2 O 2 ), hydroxyl radical (OH), and singlet oxygen ( 1 O 2 ), are generated as byproducts of mitochondrial respiration

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