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The guiding clinical principle is to escalate slowly : advance only when the current step is tolerated, counsel patients in advance that symptoms tend to peak with each new step and then subside, and step back rather than stop when symptoms appear

The Effects of Tirzepatide on Kidney Disease As tirzepatide's role has been widely centered around decreasing the incidence of complications of diabetes mellitus, one must consider its impact on the development of diabetic nephropathy and chronic kidney disease (CKD)

doi: 10.2337/diabetes.52.1.124 [DOI] [PubMed] [Google Scholar] 20

Plasma C-peptide was measured using a 2-site immunenzymatic sandwich assay (Roche Diagnostics)