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3.5 CB-839 induces autophagy in CLL cell lines Because glutamine flux regulates mammalian target of rapamycin complex 1s kinase activity, which is responsible for autophagy, we assessed the effects of glutaminase inhibition on autophagy as an alternative mechanism of CB-839mediated cell death ( Figure 4A )

In fibroblast cultures, GHK-Cu administration increases collagen synthesis by 70% while simultaneously enhancing collagen quality through improved cross-linking patterns

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