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However, while these effects are desirable for some patients, it is crucial to note that results may vary based on individual skin types, treatment regimens, and dosage

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As a result, recent strategies have been shifted toward developing non-invasive drug delivery methods to improve brain drug delivery, including the use of prodrugs, nanoparticles, focused ultrasound, and intranasal (IN) delivery methods (Terstappen et al., 2021)