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This is due to the fact that M1 macrophages, which are pro-inflammatory, possess higher concentrations of inducer nitric oxide synthase (iNOS), leading to a greater production of nitric oxide free radicals and stronger protection against lipid peroxidation, when compared to M2 macrophages, which are anti-inflammatory and have lower iNOS concentrations (83)

To meet demand, both Lilly and Novo look to expand supply capacity of their GLP-1 portfolios

Any reference to biological activity or potential effects is based solely on preclinical or invitro findings and should not be interpreted as validated clinical outcomes

2023 Feb 14;17(3):2537-2553