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But their translation into routine practice necessitates rigorous evaluation of safety, durability of efficacy, and patient heterogeneity-factors that remain insufficiently addressed to date ( 4.1 Liver-selective THR agonists for metabolic and fibrotic correction Emerging pharmacological strategies have increasingly targeted THR signaling, particularly in the treatment of NASH and progressive MAFLD (158, 159)

Its main mechanism of action revolves around actin sequestration

is supported by National Institutes of Health (NIH) grants R01CA204232 and R01CA166413, a Memorial Sloan Kettering Cancer Center (MSKCC) Functional Genomic Initiative grant, as well as a National Cancer Institute (NCI) Cancer Centre core grant P30 CA008748 to MSKCC

NASH, Non-alcoholic steatohepatitis