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Results Cryo-EM structure of human DDB1-DDA1-DET1 (DDD) complex To gain structural insights into the assembly of the DDD complex, we co-transfected DDB1, DDA1 and DET1 into Expi293F cells and purified the complex using a tandem affinity purification protocol (Fig

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The Akkermansia species muciniphila has been shown to alter glucose and lipid metabolism as well as intestinal immunity 86 , to strengthen the integrity of the enterocyte monolayer to possibly improve intestinal barrier integrity 87 , and to improve glucose tolerance and reduce visceral adipose tissue inflammation in mice fed an HFD 88