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Age-Related Decline In the body, GHK-Cu naturally occurs at concentrations of approximately 200 ng/mL in plasma at age 20, but these levels decline progressively with age to less than 80 ng/mL by age 60 - this age-related decline correlates with decreased tissue repair capacity, skin aging, and impaired regenerative responses, leading to the hypothesis that GHK-Cu decline contributes to aging phenotypes and that restoration of youthful levels through supplementation could have anti-aging benefits