The reductions noted in this trial, the team noted, were associated with long-term reductions in alcohol-related negative consequences, improvement in mental health, and aligns with improvement in self-evaluated general and psychological health in the semaglutide group in the trial, although these improvements were modest. The most common adverse effects reported were gastrointestinal, and were more frequent in the semaglutide group, but most were short-lived, and none were severe
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From a research standpoint, extensive, strain-specific multicenter trials that include comprehensive product characterization, standardized outcome measures, and sufficient follow-up are essential to establish minimal effective doses, assess the durability of effects, and identify infrequent adverse events
