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Leptin is proinflammatory and profibrotic, as it induces hepatic Kupffer cells to release inflammatory cytokines including tumor necrosis factor (TNF)-alpha as well as profibrogenic cytokines such as transforming growth factor (TGF)-beta, which induce a profibrogenic cascade in hepatic stellate cells [33]
If you feel seriously unwell, symptoms are rapidly worsening, or you cannot get advice from your prescriber, use NHS 111, urgent care or A&E as appropriate
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Assessment of bronchodilator response in patients with CF and Non-CF bronchiectasisA randomized controlled study
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