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[37], using liquid chromatography coupled to quadrupole time-of-flight with tandem mass spectrometry (LC-QTOF-MS/MS), compared the compositions of fresh and black garlic and reported major differences in amino acids and organosulfur compounds

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As monotherapy, amantadine and monoamine oxidase type B (MAO-B) inhibitors provide benefits in early PD, but the symptomatic effect is less than that of dopamine agonists and carbidopa/levodopa (L-dopa)

That put NNMT on the map as a metabolic target