Furthermore, metabolic comorbidities such as insulin resistance indirectly enhance urate reabsorption through NHE3-mediated (sodiumhydrogen exchanger 3) tubular alkalinization, creating a mechanistic link between metabolic syndrome and hyperuricemia (Gong et al., 2020
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reported that H 2 O 2 inhibited HBV replication in human hepatoma cell lines in a p53-dependent manner 87