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This has mainly derived from experimental studies, although the first results emerged over 30 years ago with the observation of reduced UA in the substantia nigra of PD patients at post mortem 10

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Heatmap representation of the unsupervised hierarchical clustering of ANOVA significant phosphorylation site stoichiometries reflected the cellular conditions well with generally highest stoichiometry in EGF-stimulated samples and lowest in kinase inhibitor treated (Supplementary Fig