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Most common symptoms of vitamin B12 include: Fatigue and weakness Shortness of breath Stomach pain Diarrhoea Vitamin B12 deficiency can also have an affect on mental well-being and cause: Headaches, Feelings of depression Anxiety Problems with memory Symptoms of this deficiency range from mild (like fatigue and weakness) to more severe issues like heart palpitations, aforementioned mental health problems, and neurological symptoms