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The receptor is a glycoprotein with an N-terminal extracellular signal peptide and, like all G protein-coupled receptors, a seven-transmembrane helix domain [6]

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The finding that GLP-1(936) acts by reducing the number of docked granules provides a simple and unifying explanation for its capacity to inhibit glucagon secretion regardless of whether it is evoked by low glucose, membrane depolarisation or a -adrenergic agonist

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