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FIGURE 1 2.1 The inhibition of the system Xc -glutathione (GSH)glutathione peroxidase 4 (GPX4) axis The system Xc is a heterodimeric antiporter on the plasma membrane, which is composed of solute carrier family seven-member 11 (SLC7A11/xCT) and solute carrier family three member 2 (SLC3A2) with a disulfide bond (Sato et al., 1999)

Here is what that looks like in practice: Study-based dosing context: We identify which doses appeared in human studies, who received them, and whether the route was subcutaneous or intravenous