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Clinical studies have revealed that PCOS patients exhibit significantly reduced gut fungal diversity and altered community structure, characterized by an increase in Ascomycota and a decrease in Basidiomycota, alongside notable enrichment of pathogenic fungi such as Candida and Malassezia (68)

TB-500 is a peptide consisting of 43 amino acids

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This study suggested for the first time that GH might regulate the peripheral clock system by affecting the expression of CLOCK and PERIOD genes in humans