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Abnormal behaviors during phase 2 are also considered to indicate inflammatory cytokine responses in the SC and a collection of responses in central tissues

The growth-promoting effects of growth hormone include muscle tissue hypertrophy (which may be desired by some but represents an anabolic effect), bone growth and remodeling (problematic after growth plates close), organ enlargement with chronic supraphysiologic doses (cardiac hypertrophy, acromegaly features), connective tissue proliferation (potentially contributing to joint pain and carpal tunnel syndrome), and cellular proliferation that may support tumor growth in susceptible individuals

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ii) Inflammation: Inflammation occurs when your bodys defense system overreacts