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Effect of DPP-4 inhibitors on microvascular events in landmark trials An adequate assessment of the effect of antidiabetic drugs on the risk of microvascular events requires trials that evaluate durations of glucose-lowering treatments administered for a decade or longer

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People with a prior history of epilepsy, seizures or antiseizure medication use were excluded

On the other hand, prolonged (16 h) stimulation with GLP-1 was shown to promote Hypoxia-Inducible Factor 1 (HIF-1) activity via induction of the mammalian Target of Rapamycin (mTOR) 16