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Nanotechnology 23(33):335707 Acknowledgments The authors thank the National Science Foundation of China (30500125) and National Science Foundation of Chongqing (2008BB5395) for supporting this work

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The findings that loss of claudin-7 expression induces sloughing of intestinal epithelial cells (claudin-7 KO mice), possibly by disrupting the complex between claudin-1, claudin-7 and 1-integrin, highlights the previously underappreciated roles of TJ proteins in cellmatrix interactions