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The rationale for combining these three peptides extends beyond simple additive effects to encompass true biological synergy, where coordinated activation of complementary pathways produces outcomes unattainable by individual components alone

Thus, the conjugate did not appear to interfere with the hypothalamic-pituitary-gonadal axis

Still, to pave the way for more widespread clinical applications of gut-based interventions, future research will need to shift emphasis on more reward phases and clinical populations, ideally using larger samples with publication of the associations regardless of their threshold as full maps and regardless of a potential confirmation or rejection of the hypothesized action on reward responses

A 4 h incubation with 100 M -EC or GSH before H 2 O 2 treatment significantly enhanced cell viability (Fig