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Schematic representation of the kidney-protective actions of DPP-4 inhibitors, including both GLP-1-dependent and independent effects on renoprotection Renoprotective Effects: DPP-4 inhibitors may protect the kidney by reducing albuminuria

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Nowadays, FOXO4-DRI studies are focused on the following aspects: osteoarthritis (senescent chondrocyte clearance), metabolic dysfunction (insulin resistance and obesity-associated senescence), neurodegeneration (eliminating senescent brain cells), and fibrotic diseases (idiopathic pulmonary and liver fibrosis)

First, it enhances glucose-stimulated insulin secretion through activation of cyclic adenosine monophosphate (cAMP)