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Disclaimer: GLP-1RA medications have a warning of risk of thyroid c-cell tumors and are contraindicated in people with a personal or family history of MTC (medullary thyroid carcinoma) or in patients with MEN 2 (multiple endocrine neoplasia syndrome type 2).

Retatrutide Adds Real Value For: Tirzepatide plateau patients with significant remaining goals: If you've been on tirzepatide at maximum tolerated dose for 6+ months, your weight loss has stalled, and you still have 1525%+ of your target weight to lose, retatrutide's additional mechanism represents a genuine pharmacological step up

Such therapies could also potentially reverse therapy resistance, considering the role of CSCs in this phenomenon