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NCT03659682

The SURMOUNT-4 trial assessed the weight maintenance with tirzepatide and had also two periods: a 36-week open-label lead-in period during which all participants took tirzepatide, followed by a 52-week double-blind treatment period during which participants were randomised to either continue on tirzepatide or switch to placebo

Mammalian target of rapamycin (mTOR) The mechanisms that account for elevated mTOR activity in ADPKD are not fully understood but it appears that cAMP/PKA/ERK and AKT are upstream regulators (Distefano et al., 2009

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