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Upon binding, it activates the Gs/adenylyl cyclase/cAMP/PKA cascade, leading to glucose-dependent insulin secretion from pancreatic beta cells

& Zhuang, J

Think of NF-kB sort of like a firefighter, it sits inside cells, waiting for a signal that something is wrong (like an injury, an infection, or stress) only then does it activate and tell the cell how to defend itself