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DPP-4i could restore the inactivation of AKT and ERK signaling and inhibit NF-B activation to reduce the production of pro-inflammatory factors, including TNF-, IL-1, monocyte chemoattractant protein-1 (MCP-1), ICAM-1 and TGF- (169, 170)

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In addition, Wang et al., using organic proteomics and metabolomics approaches, identified a new mitochondrial transporter, SLC25A39, and highlighted its essential role in proliferation