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28 LOLA is a combination of endogenous amino acids that are metabolized in periportal and perivenous hepatocytes, where L-ornithine is utilized as a substrate in the urea cycle and acts as an activator of carbamoyl phosphate synthetase, the rate limiting enzyme of the urea cycle

MEDI0382, a GLP/glucagon receptor dual agonist, significantly reduces hepatic fat content in subjects with type 2 diabetes mellitus

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doi: 10.1038/s41419-023-06057-8 150 RoskoskiRJ