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Furthermore, endothelial cells in the TME activate the expression of the Notch1 receptor (N1ICD) and facilitate peritoneal metastasis

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A meta-analysis based on the human genome showed that high-risk individuals were 2.5 times more likely to have hypothyroidism than those at low genetic risk

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Regular screening every 1-2 years catches disease early in high-risk patientswaiting until symptoms appear often means 60-70% of kidney function is already lost

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