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The resulting GSH or homoglutathione (-L-glutamyl-L-cysteinyl--alanine) conjugates were usually much less toxic and more water-soluble than the original xenobiotics (Brown and Neighbors, 1) (Bartling et al., 2002

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Mechanism of action Acitretin exerts its effects by binding to retinoic acid receptors (RARs) and retinoid X receptors (RXRs), leading to gene transcription changes that mediate its anti-proliferative and anti-inflammatory properties