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The availability of oral formulations addresses patient preferences for non-injectable medications while the entry of additional manufacturers beyond the current duopoly is expected to improve supply availability and create pricing competition that will facilitate broader access
A small randomized controlled trial found that application of 1% ajoene cream to the skin twice daily was as effective in treating tinea pedis (fungal skin infection known as athletes foot) as 1% terbinafine (Lamisil) cream (86)
Recent regulatory guidance documents, such as the 2025 Australian Therapeutic Goods Administration (TGA) guidance on the quality of listed probiotic medicines and broader discussions on LBPs from 2020, underscore the necessity for strain-level identification, validated enumeration techniques, and explicit labeling of potency and storage conditions (570, 571)
Likewise, loss-of-function mutations in another Ca 2+ -channel Transient receptor potential cation channel, subfamily M, member 2 (TRPM2) are also associated with human bipolar disorder and Trpm2 null mice display manic-like behaviours [29]
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