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Instead, ghrelin may interact with the hypothalamic neuropeptide orexin to drive CPP for palatable food given that CPP expression for a high fat diet is absent in orexin KO mice and in wildtype mice receiving ip injection of the orexin receptor antagonist SB-334867 [63]

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Conclusion The most important takeaway from this study and from Shungus and Natelson work is that the same central finding an overemphasis on anaerobic energy production- is showing up in both ME/CFS and FM, and it appears to be showing up across the body