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Standard Research Protocol 200500mcg per administration Frequency: 12 daily Administration: Subcutaneous injection Common Administration Sites Abdomen Thigh Rotate administration sites regularly

Scientific knowledge about the pharmacological actions of exogenous cannabinoids was considerably informed by the discovery of the G protein-coupled cannabinoid receptors (CB 1 and CB 2 ) and their endogenous ligands known as endocannabinoids (anandamide and 2-arachidonoylglycerol (2-AG)) which, along with their synthesis/degradation enzymes, collectively constitute the endocannabinoid system

Itaconate promotes tumor growth via oxidative phosphorylation-driven ROS generation in peritoneal tissue-resident macrophages and concomitant ROS-mediated mitogen-activated protein kinases (MAPKs) activation in tumor cells (79)