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The in vivo half-life study in hemizygous human FcRn Tg32 mice was performed at The Jackson Laboratory (JAX Services, Bar Harbor, ME, USA), which was approved by the Animal Care and Use Committee at The Jackson Laboratory

Wegovy injection initiates at 0.25 mg once weekly for four weeks and then follows a titration schedule every four weeks toward a maintenance dosage, with 2.4 mg the usual recommended maintenance dosage for weight reduction in adults and a labeled maximum of 7.2 mg once weekly for adults meeting the criteria in the label

EndocrineMetab Sci

doi: 10.1056/NEJMoa1600869 5 KilimnikGKimASteinerDFFriedmanTCHaraM