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Furthermore, APAP exposure significantly depletes glutathione [68], suggesting that repeated exposure to the drug is potentially more hazardous than a single exposure.Although APAP metabolism is well characterized, a high degree of variability in APAP metabolism within the pediatric population has been observed, and the factors affecting this variability are poorly understood [69]

Even standing for extended periods can become difficult

Upon stress, Sestrin2 activates AMPK, which promotes the phosphorylation of tuberous sclerosis complex 2, leading to mTORC1 inhibition (Wolfson et al., 2016)

3.2 0.4-fold above vehicle) and Nile Red flow cytometry (+280 35% neutral lipid mean fluorescence intensity)