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However, the underlying mechanism for GLP-1 accomplishing this is not known, as whether or not GLP-1R is localised to the islet alpha-cell surface is a matter of debate

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The gating strategy for the live single-cell CD3- CD19- CD56- CD14+ population is presented in Supplementary Figure 1

The article lists nausea, vomiting, constipation and diarrhea as the symptoms that appear more often as the amount increases, which is why it describes documented tolerability at lower amounts as a prerequisite before a provider considers intensifying therapy