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As collagen levels naturally decline with age, skin may become thinner, less firm, and more prone to wrinkles

Effects of exenatide twice daily versus sitagliptin on 24-hour glucose, glucoregulatory, and hormonal measures: a randomized, double-blind, crossover study

The above pathological changes caused the narrowing, occlusion and distortion of the vascular bed, The vessels were squeezed by regenerating nodules, and the branches of intrahepatic portal vein, hepatic vein and hepatic artery lost their normal relationship, and anastomosed branches appeared (Pu et al., 2023)

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