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This synthesis happens primarily in the liver, with some in the kidneys, before being transported to other tissues

In addition, even though supplements are safe, their excessive or incorrect use can lead to health problems

Mechanistically, the role of KHK in alcohol preference is most likely due to the role of fructose metabolism in the activity levels of aldehyde dehydrogenase (ALDH), the mitochondrial enzyme that metabolizes the toxic intermediate in ethanol metabolism, acetaldehyde

The protein encoded by ACSF2 is partially characterized as mitochondrial acyl-CoA synthetase, which catalyzes the formation of fatty acyl-CoA from ATP, CoA, and medium-chain fatty acids