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However, thymic peptides such as thymosin- and thymopoietin have precursors widely expressed outside the thymus, localized in cell nuclei, and involved in vital nuclear functions

They are generally well-tolerated and have a low risk of side effects

In bovine retinal capillary endothelial cells (BRECs) and retinas from diabetic rats, hyperglycemia-induced elevated levels of NF-B, and Bax, a pro-apoptotic gene, were sustained even after returning to normoglycemia (193)